Emergent growth cone responses to combinations of Slit1 and Netrin 1 in thalamic axon topography
نویسندگان
چکیده
Ecole Normale Supérieure, Institut de Biologie de l’ENS, IBENS, 46 rue d’Ulm, 75230 PARIS cedex 05, France INSERM, U1024, Avenir Team CNRS, UMR 8197 Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez-Consejo Superior de Investigaciones Científicas (UMH-CSIC), San Joan d’Alacant, 03550, Spain Genentech, Inc., South San Francisco, CA 94080, USA These authors contributed equally to this work These authors contributed equally to this work
منابع مشابه
Emergent Growth Cone Responses to Combinations of Slit1 and Netrin 1 in Thalamocortical Axon Topography
How guidance cues are integrated during the formation of complex axonal tracts remains largely unknown. Thalamocortical axons (TCAs), which convey sensory and motor information to the neocortex, have a rostrocaudal topographic organization initially established within the ventral telencephalon [1-3]. Here, we show that this topography is set in a small hub, the corridor, which contains matching...
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BACKGROUND Guidance molecules are normally presented to cells in an overlapping fashion; however, little is known about how their signals are integrated to control the formation of neural circuits. In the thalamocortical system, the topographical sorting of distinct axonal subpopulations relies on the emergent cooperation between Slit1 and Netrin-1 guidance cues presented by intermediate cellul...
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Background: The mammalian thalamus relays sensory information from the periphery to the cerebral cortex for cognitive processing via the thalamocortical tract. The thalamocortical tract forms during embryonic development controlled by mechanisms that are not fully understood. b-catenin is a nuclear and cytosolic protein that transduces signals from secreted signaling molecules to regulate both ...
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Recent studies have demonstrated that the topography of thalamocortical (TC) axon projections is initiated before they reach the cortex, in the ventral telencephalon (VTel). However, at this point, the molecular mechanisms patterning the topography of TC projections in the VTel remains poorly understood. Here, we show that a long-range, high-rostral to low-caudal gradient of Netrin-1 in the VTe...
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The coupling of axon guidance cues, such as netrin-1, to microtubule (MT) dynamics is essential for growth cone navigation in the developing nervous system. However, whether axon guidance signaling regulates MT dynamics directly or indirectly is unclear. Here, we report that TUBB3, the most dynamic β-tubulin isoform in neurons, directly interacts with the netrin receptor DCC, and that netrin-1 ...
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تاریخ انتشار 2012